90(15):7567-83. A. Bukreyev, I. M. Belyakov, G. A. Multifunctional pan-ebolavirus antibodies recognize a site of broad vulnerability on the ebolavirus glycoprotein. Ward and J.E. (2017). A. Bukreyev, S. S. Whitehead, C. Prussin, B. R. Murphy and P. L. Collins (2000). In: Advances in virus research, 54:423-451. 82 (24):12191-12204. 5): S475-S485. The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains. *Co-corresponding author. R. F. Russell, J. U. McDonald, M. Ivanova, Z. Zhong, A. Bukreyev, J. S. Tregoning. J. Virol 80:5958-5967. Respiratory Syncytial Virus Infection Sensitizes Cells to Apoptosis Mediated by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL). Guided by our RISES initiative, the UTMB School of Health Professionals will focus on the following strategic priorities for the 2021–2026 period: Research Activity, Influence & Impact, Student Success & Preparedness, Experiences in Clinical Settings, and Strategic Capacity & Transformation. 1994-1996. Convener of the Filoviruses Workshop, 30th Annual Meeting of American Society for Virology, University of Minnesota, Minneapolis, Minnesota. Innate immune response of bat and human cells to filoviruses: commonalities and distinctions. B. R. West, A. USA 104(23):9788-9793. L. B. C. Le Nouën S. Munir, S. Losq, C. C Winter, T. McCarty, D. A Stephany, K. L Holmes, A. Bukreyev, R. L. Rabin, P. L Collins, and U. J Buchholz (2009). P. A. Ilinykh, B. Tigabu, A. Ivanov, T. Ammosova,  Y. Obukhov, T. Garron, N. Kumari, D. Kovalskyy, M. O. Platonov, V. S. Naumchik,A. Topoisomerase II inhibitors induce DNA Damage dependent interferon responses circumventing Ebola virus immune evasion. Academic Press. (2017). Master of Science in Clinical Laboratory Sciences. Cell Reports 24: 1802-1815. Doranz, H.L. (2017). Departments of Pathology and Microbiology & Immunology. PLOS Pathogens 21(12):e1006031. J. H. Kuhn. Altman, S. Hui, B.M. The article was chosen for J. Virol. Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 and its targeting for the inhibition of viral transcription. Ebola binding to Tim-1 on T-Lymphocytes induces a cytokine storm. Mol. Future Medicine: Future Virology 2 (6):537-541. J. Virol. Overview. 77:9156-9172. Acad. (2017). Antiviral Research 150:193-201. 289(33): 22723-38. Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody. In 2016, the UTMB Department of Clinical Laboratory Science implemented the first Doctorate in Clinical Laboratory Science (DCLS) program in Texas. Ward, A. Bukreyev,* and J. E. Crowe, Jr.* (2016) Cross-reactive and potent neutralizing antibody responses in human survivors of natural Ebolavirus infection. Z. Wec, P. J. Halfmann, J. M. Brannan, A. S. Herbert, X. Qio et al. 5): S627-S635. Ward. J. Infect. (2015) Aerosolized Ebola vaccine protects primates and elicits lung-resident T-cell responses. Nonsegmented negative-strand viruses as vaccine vectors. Member of the Organizing Committee of the 6th International Symposium on Filoviruses, Galveston, Texas, March 30-April 2, 2014. A. Bornholdt, J. C. Slaughter, G. Sapparapu, T. G. Ksiazek, A. Natl. Filovirus vaccines: what challenges are left? (2018). Vaccine, 27 (10):1530-1539. A. Rialdi, L. Campisi, N. Zhao, A. C. Lagda, C. Pietzsch, J. S. Ho, L. Martinez-Gil, R. Fenouil, X. Chen, M. Edwards, G. Metreveli, S. Jordan, Z. Peralta, C. Muniz-Fontela, N. Bouvier, M. Merad, J. Jin, M. Weirauch, S. Heinz, C. Benner, H. van Bakel, C. Basler, A. Garcia-Sastre, A. Bukreyev, and I. Marazzi. The TLR4 antagonist Eritoran protects mice from lethal filovirus challenge. Dis. Baker W.S., Negi S.S, Braun. L. B. P. Younan, M. Iampietro, A. Nishida, P. Ramanathan, R. I. Santos, M. Dutta, N. M. Lubaki, R. A. Koup, M. G. Katze, and A. Bukreyev. Dr. Alex Bukreyev at the University of Texas Medical Branch and the Galveston National Laboratory reports, “Our lab tested a panel of antibodies against a real SARS-CoV-2 in biocontainment. Disabling of lymphocyte immune response by Ebola Virus. mBio 9(5): e01771-18. Trends in Microbiology 27(1):8-16. A. Berzofsky, P. L. Collins, and A. Bukreyev (2006). *Co-lead authors. Review. Cross-reactive, neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk. L. Zhang, A. Bukreyev, C. Thompson, B. Watson, M. E. Peeples, P. L Collins, and R. J. Pickles (2005). Antibody-mediated protective mechanisms induced by a trivalent parainfluenza-vectored ebolavirus vaccine. E. Ollmann Saphire , G. K. Lewis, G. Alter, A. M. L. Hastie, M. J. Headlam, N. B. Patel, A. M. Iampietro*, P. Younan*, A. Nishida, M. Dutta, N. M. Lubaki, R. I. Santos, R. A. Koup, M. G. Katze, and A. Bukreyev. J. Infect. J. Virol. In their study, Alex Bukreyev, a UTMB virologist, and his team utilized ultra-deep genetic sequencing to identify how the Ebola virus adapts to bat and human cells. Dive into the research topics where Alexander Bukreyev is active. Advances in the development of vaccines against Marburg and Ebola viruses. Cross, C.E. *Co-senior authors. 217(2):451-455. . ACS Infectious Diseases 1(8): 380-387. A. Bukreyev and P. Collins (2010). *Co-corresponding authors. mBio 8(5) e00845-17. 90(15):7567-83. Taxonomy of the order Mononegavirales: Update 2017. Science. J. Virol. M. Meyer, D. C. Malherbe and A. Bukreyev (2018). 80:5854-5861. 125(8): 3241-55. P. A. Ilinykh, J. Graber, N. A. Kuzmina, K. Huang, T. G. Ksiazek, J. E. Crowe, Jr. and A. Bukreyev (2018). Possibility and challenges of conversion of current virus species names to Linnaean Binomials. 218 (Suppl. Innate immune response of bat and human cells to filoviruses: commonalities and distinctions. (2010). This article was chosen for UTMB Press Release on October 24, 2019. Kang's Lab At Utmb is on Facebook. A. I. Flyak, X. Shen, C. D. Murin, H. L. Turner, M. L. Fusco, R. Lampley, N. Kose, P. A. Ilinykh, N. Kuzmina, A. Branchizio, H. King, L. Brown, C. Bryan, E. Davidson, B. J. Doranz, J. C. Slaughter, G. Sapparapu, C. Klages, T. G. Ksiazek, E. O. Saphire, A. Cell 160(5) 893-903. T. Ammosova, C. A. Pietzsch, Y. Saygideğer, A. Ilatovsky, X. Lin, A. Ivanov, N. Kumari, M. Jerebtsova, A. Kulkarni, M. Petukhov, A. Üren, A. Bukreyev* and Sergei Nekhai* (2018). July 17, 2010. Nature Microbiology 3(6):670-677. (2014) A comprehensive proteomic view of responses of A549 cells to human respiratory syncytial virus infection. PLOS Pathogens 14(4):e1006932. Expression of immunomodulating molecules by recombinant viruses: Can the immunogenicity of live virus vaccines be improved? The article was chosen for UTMB press release on 05/02/13. The article was chosen for UTMB and the Vanderbilt University press releases on 1/21/2016, and was highlighted in Nature 529, 440. Bestel online of kom langs in onze winkels. J. Infect. Natl. N. A. Kuzmina, P. Younan, P. Gilchuk, R. I. Santos, A. I. Flyak, P. A. Ilinykh, K. Huang,   N. M. Lubaki, P. Ramanathan, J. E. Crowe, Jr. and A. Bukreyev (2018). Virol. A. I. Flyak, N. Kuzmina, C. D. Murin, C. Bryan, E. Davidson, P. Gilchuk, C. P. Gulka, P. A. Ilinykh, X. Shen, P. Ramanathan, K. Huang, H. Turner, M. L. Fusco, R. Lampley, N. Kose, H. King, G. Sapparapu, B. J. Doranz, T. G. Ksiazek, D. W. Wright, E. Ollmann Saphire, A. Virology 377 (2):255-264. J. DiNapoli, B. Nayak, L. Yang, B. W. Finneyfrock, A. Cook, H. Anderson, F. Torres-Velez, B. Murphy, S. Samal, P. Collins, and A. Bukreyev (2010). G. K. Amarasinghe, Y. Bào, C. F. Basler, S. Bavari, M. Beer, N. Bejerman, K. R. Blasdell, A. Bochnowski, T. Briese, A. Bukreyev et al. Springer, ISBN 3-211-20671-X. (2017). Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection. A. Bukreyev,  M. E. Serra, F. R. Laham, S. R. Kleeberger, P. L. Collins, and F. P. Polack (2006). Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse. Acad. (2017). 5): S327-S334. Departments of Pathology and Microbiology & Immunology Phone: (409) 772-2829 Lab: (409) 772-2831 Email: alexander.bukreyev@utmb.edu Bukreyev Laboratory Page 81:6379-6388. (2018). spotlight. J. DiNapoli, A. Kotelkin, L. Yang, B. R. Murphy, S. Samal, P. L. Collins, and A. Bukreyev (2007). P. A. Ilinykh, Xiaoli Shen, A. I. Flyak, N. Kuzmina, T. G. Ksiazek, J. E. Crowe, Jr., A. Bukreyev. J. Fang, C. Pietzsch, P. Ramanathan, R. I. Santos, P. A. Ilinykh, M. A. Garcia-Blanco, A. Bukreyev and S. S. Bradrick (2018). Convener of the Viral Epidemiology Workshop, 32th Annual Meeting of American Society for Virology, The Pennsylvania State University, University Park, Pennsylvania. *Co-corresponding author. (2018). Nature Communications 10 (1):1788. Characterization of antibody responses to filovirus infections in humans, in collaboration with Dr. James Crowe, Jr. (Vanderbilt University). Antibody repertoires to the same Ebola vaccine antigen are differentially affected by vaccine vectors. Alexander BUKREYEV, Professor of University of Texas Medical Branch at Galveston, Texas (UTMB) | Read 230 publications | Contact Alexander BUKREYEV *Co-corresponding author. J. Virol. J. Virol. PLOS Pathogens 13(5):e1006397. Dr. Soong’s research focuses on New World cutaneous, mucosal and visceral leishmaniasis. J. Virol. Runners' lab is de specialist voor lopers, traillopers en wandelaars. The HPIV3-vectored intranasal vaccine against Ebola virus is immunogenic in HPIV3-immune animals. Can Ebola virus vaccines have universal correlates of protection? Journal of Infectious Diseases 218(Suppl. PLOS Pathogens 14(8):e1007204. Genome sequencing of emerging viral pathogens, including paramyxoviruses and filoviruses. 71:8973-8982. Cell Host & Microbe 23(1):101-109. A. Bukreyev, S. Whitehead, B. Murphy, and P. Collins (1997). Antiviral Research 158:288-302. A. Kotelkin, I. M. Belyakov, L. Yang, J. Development of therapeutic human monoclonal antibody treatments. J. Virol. L. B. State Research Center of Virology and Biotechnology "Vector", Koltsovo, Russia. Acad. ICTV, Viruses, in press. N. Freiberg, S. Nekhai, and A. Bukreyev (2014). Barrett, PhD Professor, Departments of Pathology and Microbiology & Immunology John D. Stobo, MD Distinguished Chair in Vaccinology … A. I. Flyak, P. A. Ilinykh, C. D. Murin, T. Garron, X. Shen, M. L. Fusco, T. Hashiguchi, Z. Successful topical respiratory tract immunization of primates against Ebola virus. J. Virol. J. Virol. USA 110(14):5576-5581. J. M. DiNapoli, B. R. Murphy, P. L. Collins, and A. Bukreyev (2008). A. Bornholdt, J. C. Slaughter, G. Sapparapu, T. G. Ksiazek, A. Epub on Apr 28, 2016. B. Kimble, D. C. Malherbe, M. Meyer, B. M. Gunn, M. M. Karim, P. A. Ilinykh, M. Iampietro, K. S. Mohamed, S. Negi, P. Gilchuk, K. Huang, Y I. Wolf, W. Braun, J. E. Crowe Jr., G. Alter, A. Bukreyev (2018). Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody. A. Bukreyev, I. M. Belyakov, J. J. Infect. Our group focuses on development of vaccines, antibody treatments and small molecule treatments against filoviruses Ebola and Marburg and on investigation of the mechanisms of their high pathogenicity. A. Bukreyev, M. H. Skiadopoulos, B. R. Murphy, and P. L. Collins. Comparative immunology of bats as a reservoir of emerging viral infections. Turner, T. Alkutkar, R. Flinko, C. Orlandi, R. Carnahan, R. Nargi, R.G. A. Bukreyev, E. Camargo, and P. Collins. Newcastle disease virus-vectored vaccines expressing the hemagglutinin or neuraminidase protein of H5N1 highly pathogenic avian influenza virus protect against virus challenge in monkeys. Effects of human respiratory syncytial virus, metapneumovirus, paramyxovirus type 3, and influenza A virus on the ability of human dendritic cells to activate autologous CD4 T cells. Lancet. Development of therapeutics targeting filoviral replication and interferon-antagonist functions (in collaboration with Dr. Sergei Nekhai and Dr. Chris Basler). The Ebola interferon inhibiting domains attenuate and dysregulate cell-mediated immune responses. MCP M114.041129. Global phosphoproteomic analysis of Ebola virions reveals a novel role for VP35 phosphorylation-dependent regulation of genome transcription Cellular and Molecular Life Sciences *Co-corresponding author. G. K. Amarasinghe, N. A. Ceballos, A. C. Banyard, C. F. Basler, S. Bavari, A. J. Bennett, K. R. Blasdell, T. Briese, A. Bukreyev, Y. Cai, et al. SHP Strategic Plan. J. Virol. The National Institutes of Health Merit Award in Recognition of Outstanding Contributions and Efforts in Support of NIAID Mission. In 2017-2018, UTMB CLS graduates earned 100% ASCP Board of Certification one-year pass rate. Review. Ward, A. Bukreyev*, and J. E. Crowe*, Jr. (2018). M. Iampietro, R. I. Santos, N. M. Lubaki and A. Bukreyev (2018). Syst. Immunity. Implementation of objective PASC-derived taxon demarcation criteria for official classification of Filoviruses. Nature Microbiology 3(6):670-677. 79: 13275-13284. , N. Kuzmina, C. D. Murin, C. Bryan, E. Davidson, P. Gilchuk, C. P. Gulka, P. A. Ilinykh, X. Shen, P. Ramanathan, K. Huang, H. Turner, M. L. Fusco, R. Lampley, N. Kose, H. King. Our research includes the following specific topics: Pyatigorsk Pharmaceutical Institute, Pyatigorsk, Russia. 81(32):13105-13111. The article was chosen for Icahn School of Medicine at Mount Sinai press releases on 4/28/2016. degree in electrical and computer engineering and physics from the University of Florida, Gainesville, FL, USA, in 2013. P. A. Ilinykh, B. Tigabu, A. Ivanov, T. Ammosova,  Y. Obukhov, T. Garron, N. Kumari, D. Kovalskyy, M. O. Platonov, V. S. Naumchik, A. N. Freiberg, S. Nekhai, and A. Bukreyev (2014). Granulocyte-macrophage colony-stimulating factor expressed by recombinant respiratory syncytial virus attenuates viral replication and increases the level of pulmonary antigen-presenting cells. Ebola virus (EBOV) in humans causes a severe illness with high mortality rates. American Society for Virology Program Planning Committee, 2011-2013. A. Rialdi, L. Campisi, N. Zhao, A. C. Lagda, C. Pietzsch, J. S. Ho, L. Martinez-Gil, R. Fenouil, X. Chen, M. Edwards, G. Metreveli, S. Jordan, Z. Peralta, C. Muniz-Fontela, N. Bouvier, M. Merad, J. Jin, M. Weirauch, S. Heinz, C. Benner, H. van Bakel, C. Basler, A. Garcia-Sastre, A. Bukreyev, and I. Marazzi. Mol. Protein phosphatase-1-targeting small molecule C31 inhibits Ebola virus replication. 218(Suppl. (2015) High-throughput minigenome system for identifying small molecule inhibitors of Ebola virus replication. (2018). B. R. West, A. 93(4): e01845-18. J. Clin. Convener of the Vaccine and Viral Vectors III Workshop, 28th Annual Meeting of American Society for Virology, University of British Columbia, Vancouver, Canada. Respiratory syncytial virus can tolerate an intergenic sequence of at least 160 nucleotides with little effect on transcription or replication in vitro and in vivo. J Biol. What are the risks - hypothetical and observed - of recombination involving live vaccines and vaccine vectors based on nonsegmented negative strand RNA viruses? Proc. The delivery of cytokines by recombinant virus in early life alters the immune response to adult lung infection. (2015) The partial attenuation of Small Hydrophobic (SH) gene deleted RSV is associated with elevated IL-1β responses. Our Lab focuses on investigation of the mechanisms of the high pathogenicity of viruses Ebola, Marburg and Lassa and development of vaccines and antibody treatments against these viruses. Delivery to the lower respiratory tract is required for effective immunization with Newcastle disease virus-vectored vaccines intended for humans. P. Younan, M. Iampietro, A. Nishida, P. Ramanathan, R. I. Santos, M. Dutta, N. M. Lubaki, R. A. Koup, M. G. Katze, and A. Bukreyev. Infection of ciliated cells by parainfluenza virus type 3 in an vitro model of human airway epithelium. J. Harker, A. Bukreyev, P. Collins, B. Wang, J. S. Tregoning, and P. J. M. Openshaw (2007). development of genetically modified filoviruses from the DNA-copies of their genomes and use of mini-genomes), immunological tools such as multi-parameter flow cytometry, and human immune cells and animal models. Cell 174(4):938-952. Ebola Virus Shed GP Triggers Differentiation, Infection and Death of Monocytes Through TLR4 Activation. Proc. Mucosal immunization protects monkeys against SARS coronavirus infection. Ilinykh, K. Huang, N. Kuzmina, P.X. Shieh,  P. E. Rollin, B. R. Murphy, P. L. Collins, and A. Sanchez (2006). 92(21):e00426-18. Disruption of phosphatidylserine synthesis or trafficking reduces infectivity of Ebola virus. Journal of Virology JVI01845-18R1 in press. This project will be focused on the innate immunity of bats. Ilinykh, K. Huang, N. Kuzmina, P.X. If you are experiencing a sudden or severe change in your health, or otherwise need an immediate response, call 911 or contact your provider's office by telephone. Neutralizing antibodies from human survivors target a conserved site in the ebolavirus glycoprotein HR2/MPER regions. Cell. Disabling of lymphocyte immune response by Ebola Virus.PLOS Pathogens 14(4):e1006932. USA 99:16987-16991. Development of therapeutic human monoclonal antibody treatments for filoviruses, in collaboration with Dr. James Crowe, Jr. (Vanderbilt University). Journal of Infectious Diseases 218 (Suppl. The UTMB Department of Clinical Laboratory Sciences has the career path for you. (2017). Cross-reactive, neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk. Biol. (2017). B. Proc. Review. Bats seem to be natural reservoirs for coronaviruses and now, new research from the University of Texas Medical Branch (UTMB) at Galveston indicates the small mammals are also kind hosts to Ebola. Paessler S, Aguilar P, Anishchenko M, Wang HQ, Aronson J, Campbell G, Cararra AS, Weaver SC.The hamster as an animal model for eastern equine encephalitis--and its use in … P. Younan, P. Ramanathan, J. Graber, F. Gusovsky, and A. Bukreyev. development of genetically modified filoviruses from the DNA-copies of their genomes and use of mini-genomes), immunological tools such as multi-parameter flow cytometry, and human immune cells and animal models. S. S. Whitehead, A. Bukreyev, M. N. Teng, C.-Y. The University of Texas Medical Branch at Galveston, Graduate Training in Experimental Pathology, Pathology Residency & Fellowship Program, Paul Brindley Distinguished Professorship, Pathology Microscope Imaging Core Laboratory, 2018 DMT Conference UTMB Faculty & Staff Registration. J. Infect. 125(8): 3241-55. Institution: University of Texas Medical Branch at Galveston. spotlight. Sci. Virus Infection by Human Antibodies Isolated from Survivors. E. O. Saphire, S. L. Schendel, M. L. Fusco, K. Gangavarapu, B. M. Gunn, A. M. Meyer, E. Huang, O. Yuzhakov, P. Ramanathan, G. Ciaramella, and A. Bukreyev. Disruption of phosphatidylserine synthesis or trafficking reduces infectivity of Ebola virus. P. L. Collins, A. Bukreyev, and B. R. Murphy (2008). Staufen1 interacts with multiple components of the Ebola virus ribonucleoprotein and enhances viral RNA synthesis. Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors. 5): S418-S422. J. Virol. M. Meyer, T. Garron, N. M. Lubaki, C. E. Mire, K. A. Fenton, C. Klages, G. G. Olinger, T. W. Geisbert, P. L. Collins, and A. Bukreyev (2015) Aerosolized Ebola vaccine protects primates and elicits lung-resident T-cell responses. J. Virol. Topoisomerase II inhibitors induce DNA Damage dependent interferon responses circumventing Ebola virus immune evasion. Cell Reports 24: 1802-1815. Nature Structural & Molecular Biology 26(3):204-212. 11(5):108-127. Firestone, M. St. Clair, W. R. Elkins, P. L. Collins, and B. R. Murphy (1999). Ebolavirus chimerization for the development of a mouse model for screening of Bundibugyo-specific antibodies. Kirchdoerfer., K. M. Hastie, A. Sangha, J. Meiler, G. Alter, A. Bukreyev, J. E. Crowe, Jr., and E. Ollmann Saphire. Phosphorylated VP30 of Marburg Virus is a Repressor of Transcription. Ward, A. W. Rimoin, A. Bukreyev*, and J. E. Crowe, Jr*. Ward and J.E. Cell 164(3): 392-405. King, B. R. West, C. L. Moyer, P. Gilchuk, A. Flyak, P. A. Ilinykh, R. Bombardi, S. Hui, K. Huang, A. Bukreyev, J. E. Crowe, Jr. and E. Ollmann Saphire (2019). Our research is supported by grants from NIH and DoD. July 16, 2011. 87(13):7471-7485. S. Munir, C. Luongo, C. Le Nouen, U. J. Buchholz, P. L. Collins, and A. Bukreyev (2008). Review article. Recovery of infectious respiratory syncytial virus expressing an additional, foreign gene (1996). The human respiratory syncytial virus non-structural protein 1 regulates type I and type II interferon pathways. (2018). N. M. Lubaki, P. Ilinykh, C. Pietzsch, B. Tigabu, A. N. Freiberg, R. A. Koup, and A. Bukreyev (2013). The TLR4 antagonist Eritoran protects mice from lethal filovirus challenge. Staufen1 interacts with multiple components of the Ebola virus ribonucleoprotein and enhances viral RNA synthesis. G. Liu, P. Nash, B. Johnson, C. Pietzsch, M. Ilagan, A. Bukreyev, C. Basler, T. Bowlin, D. Moir, D. Leung, and G. Amarasinghe. Vodzak, S. Li, A. Okoli, M. Ibeawuchi, Ohiaeri, G.K. Lewis, G. Alter, A. Bukreyev, E. Ollmann Saphire, T.W. mBio. P. A. Ilinykh, J. Graber, N. A. Kuzmina, K. Huang, T. G. Ksiazek, J. E. Crowe, Jr. and A. Bukreyev (2018). J. Infect. Experimental evolution of viruses in bats. The article was chosen for UTMB press release on 05/02/13. Proteomics. Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging pathogens. Interferon gamma expressed by a recombinant respiratory syncytial virus attenuates virus replication and yet maintains immunogenicity in mice. Ph ILINYKH of University of Texas Medical Branch at Galveston, Texas (UTMB) | Read 72 publications | Contact Ph ILINYKH J. Virol. M. Meyer, A. Yoshida, P. Ramanathan, E. Ollmann Saphire, P. Collins, J. E. Crowe Jr., S. Samal and A. Bukreyev (2018). B. Characterization of antibody responses to virus infections in humans. King, B. R. West, C. L. Moyer, P. Gilchuk, A. Flyak, P. A. Ilinykh, R. Bombardi, S. Hui, K. Huang, A. Bukreyev, J. E. Crowe, Jr. and E. Ollmann Saphire (2019). Join Facebook to connect with Kang's Lab At Utmb and others you may know. Chimeric respiratory paramyxovirus bearing Ebola glycoprotein as a sole envelope protein for prevention of Ebola virus infection. Non-commercial Partnership "Center of Modern Medical Technologies TEMPO". (2018). A. Bukreyev, A. Marzi, F. Feldmann, L. Zhang, L. Yang, J. M. Ward, D. Dorward, R. J. Pickles, B. R. Murphy, H. Feldmann, and P. L. Collins (2009). 79:9515-9526. (2016) Chimeric filoviruses for identification and characterization of monoclonal antibodies. Expression of interleukin-4 by recombinant respiratory syncytial virus is associated with accelerated inflammation and a non-functional cytotoxic T lymphocyte response following primary infection but not following challenge with wild-type virus. CDC Goes to Highest Alert Over Zika Outbreak | US News. The article was chosen for UTMB press release and NIH press release on 7/13/2015. P. A. Ilinykh, R. I. Santos, B. M. Gunn, N. A. Kuzmina, X. Shen, K. Huang, P. Gilchuk, A. I. Flyak, P. Younan, G. Alter, J. E. Crowe, Jr., and A. Bukreyev (2018). PLOS Pathogens 21(12):e1006031. M. Edwards, C. Pietzsch, T. Thibaut; M. Shaw, A. Bukreyev, C. Basler. Using mouse and hamster infection models, her team wants to understand how innate and adaptive immune responses against Leishmania parasites are regulated, which host- and parasite-derived factors are responsible for disease pathogenesis, and which molecules can be incorporated in the vaccine regimen. Dis. A. Berzofsky, and P. L. Collins (2005). The article was chosen for J. Virol. Feb 15, 2018, 11:03 AM by Mary Jo Singleton The University of Texas Medical Branch at Galveston, Graduate Training in Experimental Pathology, Pathology Residency & Fellowship Program, Paul Brindley Distinguished Professorship, Pathology Microscope Imaging Core Laboratory, 2018 DMT Conference UTMB Faculty & Staff Registration, American Society for Virology, Full Member. J. Infect. National Institute of Allergy and Infectious Diseases Performance Award in Recognition of Special Achievement in Support of the Mission of the National Institute of Allergy and Infectious Diseases. 5): S335-S345. Gunn, A.L. Vodzak, S. Li, A. Okoli, M. Ibeawuchi, Ohiaeri, G.K. Lewis, G. Alter, A. Bukreyev, E. Ollmann Saphire, T.W. J. Virol. 217(2):451-455. Rational design of live-attenuated recombinant vaccine virus for human respiratory syncytial virus by reverse genetics. Ward, A. Bukreyev,* and J. E. Crowe, Jr. (2016) Cross-reactive and potent neutralizing antibody responses in human survivors of natural Ebolavirus infection. The National Institute of Health Fellows Award for Research Excellence. The article was chosen for UTMB press releases on 12/01/2016. Proc. J. Clin. J. Virol. Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection. 73:3438-3442. Development of mucosal respiratory tract vaccines against filoviruses based on human and non-human paramyxovirus vectors. B. A. Harker, M. Goritska, C. Johansson, A. Bukreyev, P. Collins, and P. J. Openshaw (2013). A. Bukreyev and P. Collins (2008). Infection and maturation of monocyte-derived human dendritic cells by human respiratory syncytial virus, human metapneumovirus, and human parainfluenza virus type 3. A. Bukreyev, M. H. Skiadopoulos, J. McAuliffe, B. R. Murphy, P. L. Collins and A. C. Schmidt (2002). P. Younan, M. Iampietro and A. Bukreyev (2018). Department: Department of Pathology. The article was chosen for UTMB and the Vanderbilt University press releases on 5/26/2015. Dis. A. Bukreyev, L. Yang, B. Murphy, and P. Collins (2010). J. Virol. Our research includes experiments in a BSL-2 labs and in BSL-4 labs of the Galveston National Laboratory. Our research includes experiments in a BSL-2 lab and in BSL-4 labs of the Galveston National Laboratory. Alexander Bukreyev: Associated Profiles ; Professor, Pathology and Microbiology & Immunology, UT Medical Branch at Galveston alexander.bukreyev@utmb.edu (409) 772-2829 Web Link Lab Webpage : Ebolavirus, Viruses, Respiratory Syncytial Viruses, Marburgvirus, Vaccines, Human Parainfulenza Virus 3, Viruses, Human Respiratory Syncytial Virus Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors. Effect of co-expression of IL-2 by recombinant respiratory syncytial virus on virus replication, immunogenicity and production of other cytokines. 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